Abstract Library
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ENETS Abstract Search
Introduction: Small intestinal neuroendocrine tumors (siNETs) are rare tumors that raise several clinical and therapeutic challenges. Current treatments are not efficient, in part because of a poor understanding of their mechanisms of progression. We recently highlighted some axon guidance molecules (AGMs) that might be implicated in the progression of siNETs. Among them, we are currently focusing our efforts on the semaphorin 3F receptor neuropilin-2 (NRP2).
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Authors: Bollard J, Massoma P, Patte C, Carbonnaux M, Vercherat C,
Keywords: siNETs, progression, NRP2 ,
Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Fischer C
Authors: Detjen K, Göhrig A, Hilfenhaus G, Körner J, Lombardi M,
Keywords: Slit2, Robo1, pancreatic, NET, pNET, metastasis, mouse model,
Introduction: Dense vascularization and high frequency of metastasis in pancreatic neuroendocrine tumors (pNET) suggest a central role for the interaction of tumor cells and vessels. Slit2 and its receptors Robo1 and Robo4 act as guidance cues in neurogenesis, angiogenesis and epithelial morphogenesis, and hence represent attractive candidate regulators at the tumor cell/stroma interface.
Conference: 10th Annual ENETSConcerence (2013)
Presenting Author: Fischer C
Authors: Detjen K, Hilfenhaus G, Göhrig A, Körner J, Welzel M,
Keywords: Axon guidance, Slit2, Robo, NET, metastases, motility,
#604 Expression of Netrin-1 and its Receptors in pNETs
Introduction: Netrin-1, a member of axon guidance molecules, and its dependence receptors (DCC, UNC5, neogenin) is involved in several cancer types (breast, neuroblastoma, colon etc) but its role in pNETs remains unknown.
Conference: 10th Annual ENETSConcerence (2013)
Presenting Author:
Authors: Benslama N, Bollard J, Massoma P, Vercherat C, Hervieu V,
Keywords: netrin-1, pNET, progression,
Introduction: Semaphorin family, a part of axon guidance molecules, is involved in many types of epithelial cancers. However, little is known about its potential function in GEP-NETs.
Conference: 10th Annual ENETSConcerence (2013)
Presenting Author:
Authors: Bollard J, Massoma P, Blanc M, Vercherat C, Lepinasse F,
Keywords: semaphorins, progression, biomarker,